There are a number of very isolated places, such as a few beaches on tropical islands inaccessible except by boat.
For example, few people have been to the beaches at the base of the tall volcanic cliffs on Molokai.
But isolated does not necessarily mean remote, it just means seldom or rarely visited.
The claim for the most remote inhabited island goes to Tristan da Cunha, population 270. It is 1700 plus miles from Africa and a little over 2000 miles from South America. It’s out there.
You can read about it here:
La Rincinada, Peru located in the Peruvian Andes at an elevation of 17,000 feet, is a very remote mining town. It’s listed in the top 10.
Antarctica certainly also comes to mind, as do the Kerguelen Islands in the southern Indian Ocean. So does Pitcairn Island from “Mutiny on the Bounty” fame.
In the northern hemisphere, the honor goes to Alert, Nunavut, Canada located 500 miles south of the North Pole. It has 5 year round residents. There is also a Canadian weather laboratory located there.
When we begin space exploration beyond the earth once more, our astronauts will find themselves in far more hostile and distant places, but orbiting earth 249 miles up in the space station must seem quite remote.
Personally, I enjoy people. I would enjoy visiting any of these distant places briefly and I just visited Molokai, albeit by helicopter.
It wouldn’t take long though and I would miss those friendly faces of my family and friends.